EPITHELIX

Mucolytic activity evaluation on a fully differentiated human airway epithelium (MucilAir™)

Aim:

The aim of this assay is to perform a short-term (1 and 4 days) evaluation of the effect of compounds on mucociliary clearance, cilia beating frequency and mucus secretion on a fully differentiated human airway epithelium (MucilAir™).
The end-points listed below are quantified:

Effect on mucolytic activity

Effect on MucilAir
x Effect on MucilAir
Effect on MucilAir2
x Effect on MucilAir2

Effect of isoproterenol and apical saline solution on MucilAir™-Normal after 24h exposure. Isoproterenol significantly increases both cilia beating frequency and mucociliary clearance.

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