The aim of this assay is to perform a short-term (1 and 4 days) evaluation of the effect of compounds on mucociliary clearance, cilia beating frequency and mucus secretion on a fully differentiated human airway epithelium (MucilAir™).
Mucolytic activity evaluation
Illustration of cilia beating and mucociliary clearance on MucilAir™
Enhancement of mucolytic activity in normal MucilAir™
Effect of isoproterenol and apical saline solution on MucilAir™-Normal after 24h exposure. Isoproterenol significantly increases both cilia beating frequency and mucociliary clearance.
Mucociliary clearance restoration in disease state (Mucilair™-CF)
Mucociliary clearance on MucilAir™-CF, untreated
Mucociliary clearance on MucilAir™-CF, treated