Publications
Establishment of a Human 3D Tissue-Based Assay for Upper Respiratory Tract Absorption
Applied In Vitro Toxicology
Wiebke Hoffmann, Julieta Gradinaru, Lucian Farcal, Mireille Caul-Futy, Song Huang, Ludovic Wiszniewski, Nikolaos Parissis, Siegfried Morath, Salvador Fortaner, Thomas Cole, Emilie Reginato, Pierre-Alain Carrupt, Samuel Constant, Sandra Coecke
immune responsecytokinesmucociliary clearancecytotoxicityrhinoviruspathogenesisrespiratory viruspersistence
Propagation of respiratory viruses in human airway epithelia reveals persistent virus-specific signatures
Journal of Allergy and Clinical Immunology
Manel Essaidi-Laziosi, Francisco Brito, Sacha Benaoudia, Léna Royston, Valeria Cagno, Mélanie Fernandes-Rocha, Isabelle Piuz, Evgeny Zdobnov, Song Huang, Samuel Constant, Marc-Olivier Boldi, Laurent Kaiser, Caroline Tapparel
alveolarinfectionsbronchial3d modelshuman lung tissue
Human Pulmonary 3D Models For Translational Research
Biotechnology Journal
Katja Zscheppang, Johanna Berg, Sarah Hedtrich, Leonie Verheyen, Darcy E. Wagner, Norbert Suttorp, Stefan Hippenstiel, Andreas C. Hocke
lung epithelialnhbeinfluenzaanthrax
Advances and Remaining Challenges in the Study of Influenza and Anthrax Infection in Lung Cell Culture
Challenges
Joshua D. Powell, Timothy M. Straub
cigarette smokevitrocell systemsmucilairnovel tobacco products
Application of a direct aerosol exposure system for the assessment of biological effects of cigarette smoke and novel tobacco product vapor on human bronchial epithelial cultures
Regulatory Toxicology and Pharmacology
Shinkichi Ishikawa, Kazushi Matsumura, Nobumasa Kitamura, Kanae Ishimori, Yuichiro Takanami, Shigeaki Ito
viral tropismcell bindingcell binding assayrespiratory infectionsneuronsgastrointestinal tractcaco-2 cellsviral replication
A VP1 mutation acquired during an enterovirus 71 disseminated infection confers heparan sulfate binding ability and modulates ex vivo tropism
PLOS Pathogens
Eirini D. Tseligka, Komla Sobo, Luc Stoppini, Valeria Cagno, Fabien Abdul, Isabelle Piuz, Pascal Meylan, Song Huang, Samuel Constant, Caroline Tapparel
Spatiotemporal organization of cilia drives multiscale mucus swirls in model human bronchial epithelium
Scientific Reports
Mustapha-Kamel Khelloufi, Etienne Loiseau, Marc Jaeger, Nicolas Molinari, Pascal Chanez, Delphine Gras, Annie Viallat
gasoline direct injection exhaustgasoline particle filterlubrication oilmulti-cellular lung model
Assessment of lung cell toxicity of various gasoline engine exhausts using a versatile in vitro exposure system
Environmental Pollution
Christoph Bisig, Pierre Comte, Martin Güdel, Jan Czerwinski, Andreas Mayer, Loretta Müller, Alke Petri-Fink, Barbara Rothen-Rutishauser
Differential antiviral activities of RSV inhibitors in human airway epithelium
bioRxiv
Carmen Mirabelli, Martine Jaspers, Mieke Boon, Mark Jorissen, Mohamed Koukni, Dorothee Bardiot, Patrick Chaltin, Arnaud Marchand, Johan Neyts, Dirk Jochmans
inhalation toxicologydendritic cells3d human airway modelmetal oxidesnanoparticlesmucilairnanotoxicology
A practical approach to assess inhalation toxicity of metal oxide nanoparticles in vitro
Journal of Applied Toxicology
Anita C. A. Dankers, C. Frieke Kuper, Anja J. Boumeester, Babs O. Fabriek, Ingeborg M. Kooter, Mariska Gröllers‐Mulderij, Peter Tromp, Inge Nelissen, Esther K. Zondervan-Van Den Beuken, Rob J. Vandebriel