Publications
Modeling airway persistent infection of Moraxella catarrhalis and nontypeable Haemophilus influenzae by using human in vitro models
Frontiers in Cellular and Infection Microbiology (May. 2024)
Ariolli, Andrea; Canè, Martina; Di Fede, Martina; Tavarini, Simona; Taddei, Anna Rita; Buno, Kevin Pete; Delany, Isabel; Rossi Paccani, Silvia; Pezzicoli, Alfredo
Astodrimer sodium nasal spray forms a barrier to SARS-CoV-2 in vitro and preserves normal mucociliary function in human nasal epithelium
Scientific Reports (Sep. 2024)
Paull, Jeremy R. A.; Luscombe, Carolyn A.; Seta, Aynaz; Heery, Graham P.; Bobardt, Michael D.; Gallay, Philippe A.; Constant, Samuel; Castellarnau, Alex
In Vitro Assessment of Translocation and Toxicological Effects of Nicotine and Ethyl Maltol from e-Cigarettes Using Air–Liquid Interface-Cultured Bronchial Epithelial Cells
Applied In Vitro Toxicology (Mar. 2024)
Staal, Yvonne C.M.; Gremmer, Eric; Duijm, Geraly; Duistermaat, Evert; Fokkens, Paul; Lensen, Daan; Hodemaekers, Hennie M.; Maas, Lou; Remels, Alexander; Talhout, Reinskje
A Novel Bionebulizer Approach to Study the Effects of Natural Mineral Water on a 3D In Vitro Nasal Model from Allergic Rhinitis Patients
Biomedicines (Feb. 2024)
Viegas, Joana; Cardoso, Elsa M.; Bonneau, Lucile; Esteves, Ana Filipa; Ferreira, Catarina L.; Alves, Gilberto; Santos-Silva, António Jorge; Vitale, Marco; Arosa, Fernando A.; Taborda-Barata, Luís
Establishment of a human nasal epithelium model of histamine-induced inflammation to assess the activity of fexofenadine as an inverse agonist and its link to clinical benefit
Frontiers in Pharmacology (Jun. 2024)
Barbot, Anne; Lheritier-Barrand, Michele; Murrieta-Aguttes, Margarita; Leonetti, Maud; Vernaz, Jimmy; Huang, Song; Constant, Samuel; Boda, Bernadett
Pseudomonas aeruginosa breaches respiratory epithelia through goblet cell invasion in a microtissue model
Nature Microbiology (Jul. 2024)
Swart, A. Leoni; Laventie, Benoît-Joseph; Sütterlin, Rosmarie; Junne, Tina; Lauer, Luisa; Manfredi, Pablo; Jakonia, Sandro; Yu, Xiao; Karagkiozi, Evdoxia; Okujava, Rusudan; Jenal, Urs
Innovative Dual Combination Cospray-Dried Rock Inhibitor/l-Carnitine Inhalable Dry Powder Aerosols
ACS Bio & Med Chem Au (Dec. 2024)
Acosta, Maria F.; Encinas-Basurto, David; Abrahamson, Michael D.; Eedara, Basanth Babu; Hayes, Don Jr.; Fineman, Jeffrey R.; Black, Stephen M.; Mansour, Heidi M.
The small molecule inhibitor of SARS-CoV-2 3CLpro EDP-235 prevents viral replication and transmission in vivo
Nature Communications (Aug. 2024)
Rhodin, Michael H. J.; Reyes, Archie C.; Balakrishnan, Anand; Bisht, Nalini; Kelly, Nicole M.; Gibbons, Joyce Sweeney; Lloyd, Jonathan; Vaine, Michael; Cressey, Tessa; Crepeau, Miranda; Shen, Ruichao; Manalo, Nathan; Castillo, Jonathan; Levene, Rachel E.; Leonard, Daniel; Zang, Tianzhu; Jiang, Lijuan; Daniels, Kellye; Cox, Robert M.; Lieber, Carolin M.; Wolf, Josef D.; Plemper, Richard K.; Leist, Sarah R.; Scobey, Trevor; Baric, Ralph S.; Wang, Guoqiang; Goodwin, Bryan; Or, Yat Sun
An oral non-covalent non-peptidic inhibitor of SARS-CoV-2 Mpro ameliorates viral replication and pathogenesis in vivo
Cell Reports (Nov. 2024)
Zhou, Nian E.; Tang, Su; Bian, Xuelin; Parai, Maloy K.; Krieger, Inna V.; Flores, Armando; Jaiswal, Pradeep K.; Bam, Radha; Wood, Jeremy L.; Shi, Zhe; Stevens, Laura J.; Scobey, Trevor; Diefenbacher, Meghan V.; Moreira, Fernando R.; Baric, Thomas J.; Acharya, Arjun; Shin, Joonyoung; Rathi, Manish M.; Wolff, Karen C.; Riva, Laura; Bakowski, Malina A.; McNamara, Case W.; Catanzaro, Nicholas J.; Graham, Rachel L.; Schultz, David C.; Cherry, Sara; Kawaoka, Yoshihiro; Halfmann, Peter J.; Baric, Ralph S.; Denison, Mark R.; Sheahan, Timothy P.; Sacchettini, James C.
Quantitative modeling of <i>in vitro</i> data using an adverse outcome pathway for the risk assessment of decreased lung function in humans
Toxicology Letters (Mar. 2024)
Sewer, Alain; Talikka, Marja; Calvino-Martin, Florian; Luettich, Karsta; Iskandar, Anita